TNFSF12-TNFSF13 Mouse Monoclonal Antibody [Clone ID: CARL-1]
CAT#: AM26783LE-N
TNFSF12-TNFSF13 mouse monoclonal antibody, clone CARL-1, Low Endotoxin
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Specifications
Product Data | |
Clone Name | CARL-1 |
Applications | FC, FN |
Recommended Dilution | Flow cytometry. Functional application: Neutralization. |
Reactivities | Human |
Host | Mouse |
Isotype | IgG3 |
Clonality | Monoclonal |
Immunogen | Human CD255-transfected 2PK-3 cells |
Specificity | This antibody recognizes CD255 / TWEAK, a type II transmembrane protein of the TNF superfamily able to weakly induce apoptosis in many cell types. |
Formulation | Azide free phosphate buffered saline (PBS), approx. pH 7.4; 0.2 μm filter sterilized. State: Low Endotoxin State: Liquid Ig fraction |
Concentration | 1.0 mg/ml |
Purification | Protein-A affinity chromatography (> 95% pure by SDS-PAGE) |
Database Link | |
Background | CD255 / TWEAK (TNF-related weak inducer of apoptosis), a type II transmembrane protein expressed as membrane-bound and secreted form, can induce apoptosis in many tissues and cell lines through its receptor CD266 / TWEAK R. On the other hand, in endothelial cells this interaction can induce proliferation and promote angiogenesis including neovascularization of tumours. CD255 can act in a juxtacrine manner to initiate cellular responses, and induces secretion of pro-inflammatory cytokines. Besides CD266, CD255 may also bind to DR3. |
Synonyms | APO3 ligand, APO3L, DR3LG |
Reference Data |
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