VEGF Receptor 2 (KDR) (2nd Extracell. Dom.) Rat Monoclonal Antibody [Clone ID: BEP-5A1]

CAT#: AM26789PU-N

VEGF Receptor 2 (KDR) (2nd Extracell. Dom.) rat monoclonal antibody, clone BEP-5A1, Purified


USD 380.00

2 Weeks*

Size
    • 100 ug

Product Images

Specifications

Product Data
Clone Name BEP-5A1
Applications ELISA, FC
Recommended Dilution Flow Cytometry: 1.2 μg/106 cells.
ELISA: 1/200-1/400.
Cell-based ELISA: 1/200-1/400.
Reactivities Human, Porcine
Host Rat
Isotype IgG2a
Clonality Monoclonal
Immunogen Complete extracellular domain of human VEGFR-2 which has been shown to be specific for the native target molecule and its counterpart in pigs using FACscan analyses on viable, transiently-transfected human BOSC23 cells (see Fig. 1).
Selection: based on recognition of the complete native protein expressed on transfected mammalian cells.
Specificity This antibody detects VEGFR2 at the second extracellular immunoglobulin-like domain.
Formulation Phosphate buffered saline, pH 7.2
State: Purified
State: Liquid purified Ig fraction
Concentration lot specific
Purification Protein G Chromatography
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Background The vascular endothelial growth factor receptor-2 (VEGFR-2) plays an important role in the control of angiogenesis. This molecule is expressed on the surface of circulating endothelial stem cells as well as on adult vascular endothelial cells and other cell types (1). It is a 200-kDa type I transmembrane protein, consisting of a 19 amino acid leader peptide, a 744 amino acid extracellular domain made up of 7 immunoglobulin-like domains, a 24 amino acid transmembrane region and a 568 amino acid cytoplasmic domain. Interactions with VEGF ligands will stimulate angiogenesis, required in wound healing but also misused by tumours to promote their vascularization (2).
Synonyms VEGFR2, FLK1, KDR, VEGF Receptor 2
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.