IL17 (IL17A) Mouse Monoclonal Antibody [Clone ID: B-B51]

CAT#: AM31211AF-N

IL17 (IL17A) mouse monoclonal antibody, clone B-B51, Azide Free

Specifications

Product Data

• Clone Name: B-B51
• Applications: FN
• Recommended Dilution: Functional Assay: Neutralises the bioactivity of IL-17A on keratinocytes cell line HaCaT (measurement of beta Defensin-2 production).
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: Recombinant Human IL-17A.
• Specificity: This antibody recognizes both recombinant and natural IL-17A.
• Formulation: Phosphate-buffered saline.
  Sterile-filtered through 0.22 µm and treated to remove endotoxins.
  Carrier and preservative free.
  State: Azide Free
  State: Liquid purfied IgG fraction
• Concentration: lot specific
• Purification: Ion Exchange Chromatography
• Storage: Store the antibody undiluted at 2-8°C.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens interleukin 17A (IL17A)
• Database Link:
  Entrez Gene 3605 Human
• Background: Interleukin 17 (IL-17) is a pro-inflammatory cytokine produced by a subset of T helper cells that develops distinct from the Th1- and Th2- cell differentiation pathways. IL-17, also known as CTLA-8, stimulates induction of other pro-inflammatory cytokines TNF alpha, IL-1 beta, IL-6, and IL-8, and reports strongly suggest the involvement of IL-17 in several chronic inflammatory diseases such as rheumatoid arthritis, psoriasis and multiple sclerosis. TGF-ß (differentiation) and IL-23 (expansion) are required for induction and maintenance of Th17 (IL-17 producing) cells, which in turn induce the other pro-inflammatory cytokines. IL-17 (~32kDa) protein is produced and exists as a homo-dimer, has homology to a herpes virus early protein, is one of the six members (IL-17A-F) of this cytokine family, and is well characterzed and highly expressed by activated effector memory T cells.
• Synonyms: IL-17A, IL17, IL-17, CTLA8, CTLA-8

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Cytokine-cytokine receptor interaction