DR4 (TNFRSF10A) Mouse Monoclonal Antibody [Clone ID: B-N36]

CAT#: AM31248RP-N

DR4 (TNFRSF10A) mouse monoclonal antibody, clone B-N36, PE

Specifications

Product Data

• Clone Name: B-N36
• Applications: FC
• Recommended Dilution: Flow Cytometry: Use 10 µl to label 10⁶ cells or 100 µl of whole blood.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant Human TRAIL R1/Fc chimera.
• Specificity: This antibody recognises CD261, a 43-46 kDa protein.
• Formulation: Phosphate-buffered saline (PBS)
  Label: PE
  State: Lyophilised purified Ig fraction
  Stabilizer: 1% BSA
  Preservative: 0.09% Sodium Azide
  Label: R-Phycoerythrin
• Reconstitution Method: Restore with 1.0 ml deionised water.
• Purification: Ion Exchange Chromatography
• Conjugation: PE
• Gene Name: Homo sapiens tumor necrosis factor receptor superfamily member 10a (TNFRSF10A)
• Database Link:
  Entrez Gene 8797 Human
• Background: Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel death domain containing receptor was recently identified and designated DR4 (for death receptor 4)1. The ligand for this novel death receptor has been identified and termed TRAIL, which is a new member in the TNF family. DR4 is also called TRAIL receptor-1 (TRAIL-R1). DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. Like TNFR1, Fas and DR3, DR4 mediates apoptosis and NF-kB activation in many tissues and cells.
• Synonyms: APO2, DR4, Death receptor 4, TRAIL receptor 1, TRAIL-R1, TNFRSF10A

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Apoptosis, Cytokine-cytokine receptor interaction, Natural killer cell mediated cytotoxicity