IL31 Mouse Monoclonal Antibody [Clone ID: B-A51]
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Specifications
Product Data | |
Clone Name | B-A51 |
Reactivities | Human |
Host | Mouse |
Isotype | IgG2b |
Clonality | Monoclonal |
Immunogen | Recombinant human IL-31 |
Specificity | This antibody recognises recombinant IL-31. |
Formulation | Phosphate-buffered saline. Sterile-filtered through 0.22 µm. Carrier and preservative free State: Azide Free State: Liquid purified Ig fraction |
Concentration | 1.0 mg/ml |
Purification | Ion exchange chromatography |
Gene Name | Homo sapiens interleukin 31 (IL31) |
Database Link | |
Background | Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells. IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor. In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells. IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia and skin lesions, and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development. |
Synonyms | IL-31 |
Reference Data | |
Protein Families | Secreted Protein, Transmembrane |
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