CD14 Mouse Monoclonal Antibody [Clone ID: B-A8]
Other products for "CD14"
Specifications
Product Data | |
Clone Name | B-A8 |
Applications | FC |
Recommended Dilution | Flow Cytometry. |
Reactivities | Human |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Monocytes. |
Specificity | Recognises the lipopolysaccharide receptor (LPS R), a 55 kDa protein. |
Formulation | PBS without Carrier and preservatives. This product is Sterile-filtered through 0.22 µm and treated to remove endotoxins. State: Azide Free State: Liquid purified IgG fraction |
Concentration | lot specific |
Purification | Ion Exchange Chromatography |
Storage | Store the antibody undiluted at 2-8°C. |
Stability | Shelf life: one year from despatch. |
Gene Name | Homo sapiens CD14 molecule (CD14), transcript variant 1 |
Database Link | |
Background | CD14 is a 55 kDa GPI-anchored glycoprotein, constitutively expressed on the surface of mature monocytes, macrophages, and neutrophils, where serves as a multifunctional lipopolysaccharide receptor; it is also released to the serum both as a secreted and enzymatically cleaved GPI-anchored form. CD14 binds lipopolysaccharide molecule in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), an acute phase serum protein. The soluble sCD14 is able to discriminate slight structural differences between lipopolysaccharides and is important for neutralization of serum allochthonous lipopolysaccharides by reconstituted lipoprotein particles. CD14 affects allergic, inflammatory and infectious processes. |
Synonyms | CD14 |
Reference Data | |
Protein Families | Adult stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Transmembrane |
Protein Pathways | Hematopoietic cell lineage, MAPK signaling pathway, Pathogenic Escherichia coli infection, Regulation of actin cytoskeleton, Toll-like receptor signaling pathway |
Documents
Product Manuals |
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