EMA (MUC1) Mouse Monoclonal Antibody [Clone ID: CM1]

CAT#: AM31368PU-N

EMA (MUC1) mouse monoclonal antibody, clone CM1, Ascites

Product Images

Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Clone Name: CM1
• Applications: IF, IHC
• Recommended Dilution: Immunofluorescence.
  Immunohistochemistry on Frozen Sections.
  Immunohistochemistry on Paraffin Sections: 10 µg/ml.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: MUC1 antibody was raised against high molecular weight (>300 kD) glycoprotein.
• Specificity: This antibody reacts to MUC1.
• Formulation: PBS, pH 7.4 containing 0.09 % sodium azide as preservative
  State: Ascites
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Affinity chromatography on Protein A
• Storage: Store the antibody undiluted at 2-8°C.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens mucin 1, cell surface associated (MUC1), transcript variant 2
• Database Link:
  Entrez Gene 4582 Human
• Background: This gene is a member of the mucin family and encodes a membrane bound, glycosylated phosphoprotein. The protein is anchored to the apical surface of many epithelia by a transmembrane domain, with the degree of glycosylation varying with cell type. It also includes a 20 aa variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length nature of only some has been determined. Also known as Cancer-associated Antigen 15-3 (CA15-3). Cancer antigen 27.29 (CA27-29), which is expressed on most carcinoma cells, is a soluble form of MUC1.
• Synonyms: MUC-1, PEMT, Episialin, EMA, H23AG, PUM, DF3, CA 15-3

Reference Data

• Protein Families: Druggable Genome, Secreted Protein, Transmembrane