Serum Amyloid A (SAA1) Mouse Monoclonal Antibody [Clone ID: B336A]

CAT#: AM31391PU-N

Serum Amyloid A (SAA1) mouse monoclonal antibody, clone B336A, Purified


USD 865.00

2 Weeks*

Size
    • 1 mg

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Specifications

Product Data
Clone Name B336A
Applications ELISA, WB
Recommended Dilution ELISA.
Western Blot.

Recommended pairs for Sandwich Immunoassay:
Capture / Detection
AM31393PU-N / AM31391PU-N
AM31392PU-N / AM31391PU-N
AM31391PU-N / AM31393PU-N
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Human recombinant SAA, conjugated with carrier protein
Specificity This antibody recognizes native and recombinant Serum Amyloid A (SAA).
Formulation PBS, pH 7.4 containing 0.09% Sodium Azide as preservative
State: Purified
State: Liquid purified Ig fraction (>90% pure by SDS-PAGE)
Concentration lot specific
Purification Affinity Chromatography on Protein A
Conjugation Unconjugated
Storage Store the antibody undiluted at 2-8°C.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens serum amyloid A1 (SAA1), transcript variant 1
Background The Serum Amyloid A (SAA) family comprises a number of differentially expressed lipoproteins, acute phase SAA1 and SAA2, the former being a major component in plasma, and constitutive SAA's (C-SAAs). Although the liver is the primary site of synthesis of both SAA types, extrhepatic production has been reported. The in vivo concentrations increase by as much as 1000 fold during inflammation. Several studies have expressed it's importance in the diagnosis and monitoring of various diseases. Pathological SAA values are often detected in association with normal CRP concentrations. SAA rises earlier and more sharply than CRP.
SAA enhances the binding of HDL's to macrophages and thus helps the delivery of lipid to sites of injury for use in tissue repair. It is thus thought to be an integral part of the disease process. In addition, recent experiments suggest that SAA may play a "houekeeping" role in normal human tissues. Elevated levels of SAA over time predispose secondary amyloidosis, extracellular accumulation of amyloid fibrils, derived from a circulating precursor, in various tissues and organs. The most common form of amyloidosis occurs secondary to chronic inflammatory disease, particularly rheumatoid artheritis.
Synonyms SAA1, SAA2
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.