FZR1 Mouse Monoclonal Antibody [Clone ID: 4C4]
Other products for "FZR1"
Specifications
Product Data | |
Clone Name | 4C4 |
Applications | ELISA, IHC, WB |
Recommended Dilution | ELISA. Immunohistochemistry on Paraffin Sections: 5 µg/ml. Western Blot: 1/500 - 1/1000. |
Reactivities | Human |
Host | Mouse |
Isotype | IgG2a |
Clonality | Monoclonal |
Immunogen | FZR1 antibody was raised against fZR1 (AAH13413, 1 a.a. ~ 494 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
Specificity | This antibody reacts to FZR1. |
Formulation | PBS, pH 7.2 State: Purified State: Liquid purified Ig fraction |
Concentration | 0.5 mg/ml |
Purification | Affinity chromatography on Protein A |
Gene Name | Homo sapiens fizzy/cell division cycle 20 related 1 (FZR1), transcript variant 3 |
Database Link | |
Background | Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. |
Synonyms | Cdh1/Hct1 homolog, CDC20-like protein 1, Fizzy-related protein homolog, FYR, FZR, KIAA1242 |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Cell cycle, Progesterone-mediated oocyte maturation, Ubiquitin mediated proteolysis |
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