HLA Class II DR Mouse Monoclonal Antibody [Clone ID: B-C10]

CAT#: AM32426FC-N

HLA Class II DR mouse monoclonal antibody, clone B-C10, FITC, Purified


USD 280.00

2 Weeks*

Size
    • 1 ml (100 Tests)

Product Images

Specifications

Product Data
Clone Name B-C10
Applications FC
Recommended Dilution Flow Cytometry: Use 10 µl to label 106 cells or 100 µl of whole blood.
Reactivities Human
Host Mouse
Isotype IgG2b
Clonality Monoclonal
Immunogen RPMI 8866 and DAUDI cell lines.
Myeloma X63/AG.8653 x Balb/c spleen cells.
Specificity This Monoclonal antibody recognises the HLA Class II (DR) membrane.
Formulation PBS
Label: FITC
State: Purified
State: Liquid purified IgG fraction
Stabilizer: 5% BSA
Preservative: 0.09% Sodium Azide
Purification Ion Exchange Chromatography
Conjugation FITC
Background Major histocompatibility complex (MHC) class II molecules destined for presentation to CD4+ helper T cells is determined by two key events. These events include the dissociation of class II-associated invariant chain peptides (CLIP) from an antigen binding groove in MHC II alpha/beta dimers through the activity of MHC molecules HLA-DM and -DO, and subsequent peptide antigen binding. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM, -DO molecules regulate the dissociation of CLIP and the subsequent binding of exogenous peptides to HLA class II molecules (HLA-DR, -DQ and -DP) by sustaining a conformation that favors peptide exchange. RFLP analysis of HLA-DM genes from rheumatoid arthritis (RA) patients suggests that certain polymorphisms are genetic factors for RA susceptibility. HLA-B belongs to the HLA class I heavy chain paralogs. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. HLA-B and -C can form heterodimers consisting of a membrane anchored heavy chain and a light chain (beta-2-Microglobulin). Polymorphisms yield hundreds of HLA-B and -C alleles.
Synonyms HLA-DR, HLA class II histocompatibility antigen DR, MHC class II antigen DR
Reference Data

{0} Product Review(s)

0 Product Review(s) Submit review

Be the first one to submit a review

Product Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.