FPRL1 (FPR2) (Extracell. Dom) Mouse Monoclonal Antibody [Clone ID: B7H10]

CAT#: AM32960PU-N

FPRL1 (FPR2) (Extracell. Dom) mouse monoclonal antibody, clone B7H10, Purified

Product Images

Western blot analysis of extracts from 293 cells transfected with FPRL1 DNA using anti-FPRL1 antibody (Clone B7H7) at 1/2000 (0.5 ug/ml) dilution.

Specifications

Product Data

• Clone Name: B7H10
• Applications: ELISA, WB
• Recommended Dilution: ELISA: In indirect ELISA, the antibody is reactive to the peptide (ASWGGTPEERLKC) from the 2^nd Extracellular loop of Human FPRL1.
  Western Blot.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: A short peptide (ASWGGTPEERLKC) corresponding to the amino acids on the 2nd extracellular loop of Human FPRL1
• Specificity: This antibody is reactive to the peptide (ASWGGTPEERLKC) from the 2^nd Extracellular loop of Human FPRL1 and is also reactive to intact Human FPRL1.
• Formulation: 0.01M PBS, pH 7.2 without preservatives
  State: Purified
  State: Lyophilized purified IgG fraction
• Reconstitution Method: Restore with Double distillated water to adjust the final concentration to 1.0 mg/ml
• Purification: Affinity Chromatography on Protein G
• Conjugation: Unconjugated
• Storage: Upon receipt, store (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens formyl peptide receptor 2 (FPR2), transcript variant 2
• Database Link:
  Entrez Gene 2358 Human
  UniProt ID P25090
• Background: FPRL1 is a low affinity receptor to N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4). FPRL1 has been reported in phagocytes, monocytes, neutrophils, differentiated myeloid cells from bone marrow, granulocyte HL-60 cells, and synovial fibroblasts. ESTs have been isolated from blood, leukocyte, lung, and placenta libraries.
• Synonyms: N-formyl peptide receptor 2, FMLP-R-I, FPRH1, RFP, LXA4R

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Neuroactive ligand-receptor interaction