Integrin beta 4 (ITGB4) Mouse Monoclonal Antibody [Clone ID: 58XB4]
CAT#: AM33010PU-N
Integrin beta 4 (ITGB4) mouse monoclonal antibody, clone 58XB4, Purified
Specifications
Product Data | |
Clone Name | 58XB4 |
Applications | ELISA, FC, IF, IHC, IP, WB |
Recommended Dilution | ELISA. Western blotting. Immunofluorescence. Flow Cytometry. Immunoprecipitation. Imunocytochemistry of paraformaldehyde fixed cells. Immunohistochemistry on Frozen Sections. See Reference 1 for Protocols. |
Reactivities | Human |
Host | Mouse |
Isotype | IgG2a |
Clonality | Monoclonal |
Immunogen | Immunization of Balb/c mice with Integrin β4. The immunogen used to raise this antibody was the full length CD104 protein. |
Specificity | Binds specifically to integrin β4 chain(CD104) or β4 integrin, that associates with integrin α6 (CD49f) forms α6/β4 (CD49f/CD104) heterodimer. CD104 is expressed on epithelial cells (especially on the proliferative basal layer epithelial cells in skin), endothelial cells, Schwann cells, certain tumor cells and a subset of pre-T cells. |
Formulation | PBS State: Purified State: Liquid purified IgG fraction Preservative: 0.09% Sodium Azide |
Concentration | 1.0 mg/ml |
Database Link | |
Background | Integrins are heterodimers composed of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. Integrin b4 (CD104) associates with integrin α6 (CD49f) forming the α6/β4 (CD49f/CD104) heterodimer. CD104 is expressed on epithelial cells (especially on the proliferative basal layer epithelial cells in skin), endothelial cells, Schwann cells, certain tumor cells and a subset of pre-T cells. CD49f/CD104 is an adhesion receptor for laminins (especially laminin 5) and keratin filaments and is involved in the regulation of hemidesmosome formation and of cell proliferation and activation. CD104 is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
Synonyms | ITGB4, GP150 |
Reference Data |
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