IPO-38 Proliferation marker Mouse Monoclonal Antibody [Clone ID: SPM260]
CAT#: AM33249PU-S
IPO-38 Proliferation marker mouse monoclonal antibody, clone SPM260, Purified
Specifications
Product Data | |
Clone Name | SPM260 |
Applications | FC, IF, IHC |
Recommended Dilution | Flow Cytometry: 0.5-1 µg/106 cells. Immunofluorescence: 0.5-1 µg/ml. Immunohistochemistry on Formalin-Fixed Paraffin Sections: 0.5-1 µg/ml for 30 minutes at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes. Positive Control: Raji and PHA-stimulated (>12 hours) human or mouse lymphocytes. Breast and colorectal carcinomas. |
Reactivities | Human, Mouse, Rat |
Host | Mouse |
Isotype | IgM |
Clonality | Monoclonal |
Immunogen | Spleen cells of a patient with hairy cell leukemia. |
Specificity | Recognizes a protein of 14-16kDa, which is a novel nuclear antigen of proliferating cells. IPO-38 antigen is present in the nuclei of proliferating cells such as Hodgkin’s disease and non-Hodgkin’s lymphomas, different forms of leukemias, breast and colorectal carcinomas, and PHA-stimulated lymphocytes. It is not expressed in the cells of non-stimulated lymphocytes and granulocytes. IPO-38 can be a useful marker of cell proliferation during monitoring of tumor progression. Cellular Localization: Nuclear. |
Formulation | 10mM PBS State: Purified State: Liquid purified IgG fraction from Bioreactor Concentrate Stabilizer: 0.05% BSA Preservative: 0.05% Sodium Azide |
Concentration | 0.2 mg/ml |
Background | IPO-38 antigen is present in the nuclei of proliferating cells such as Hodgkin’s disease and non-Hodgkin’s lymphomas, different forms of leukemias, breast and colorectal carcinomas, and PHA-stimulated lymphocytes. It is not expressed in the cells of non-stimulated lymphocytes and granulocytes. IPO-38 can be a useful marker of cell proliferation during monitoring of tumor progression. |
Synonyms | IPO38 |
Reference Data |
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