ICT1 (MRPL58) (30-206) Mouse Monoclonal Antibody [Clone ID: AT1E9]
Other products for "MRPL58"
Specifications
Product Data | |
Clone Name | AT1E9 |
Applications | ELISA, FC, WB |
Recommended Dilution | ELISA. Western blot: Recommended starting dilution is 1:1000. Flow cytometry. |
Reactivities | Human |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Recombinant human ICT1 (30-206aa) purified from E. coli |
Specificity | This antibody detects ICT1 at aa30-206. |
Formulation | PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction |
Concentration | lot specific |
Purification | Protein-A affinity chromatography |
Storage | Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Gene Name | Homo sapiens mitochondrial ribosomal protein L58 (MRPL58), transcript variant 1 |
Database Link | |
Background | Peptidyl-tRNA hydrolase ICT1 acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. The adult colon epithelium contains 3 differentiated cell types that arise from a multipotent stem cell. Deviation from the normal maturation pathway by neoplastic transformation is thought to initiate in stem cells or their early descendants. This neoplastic-induced deviation is marked by a change in expression of several mRNAs. ICT1 is a member of the prokaryotic/mitochondrial release factor family whose expression is downregulated over 4 fold upon colon stem cell differentiation. This downregulation of ICT1 could lead to its use as a marker for detection of colon carcinomas. |
Synonyms | Digestion substraction 1, DS-1 |
Reference Data |
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