MICOS10-NBL1 Mouse Monoclonal Antibody [Clone ID: AT38G8]

CAT#: AM50052PU-N

MICOS10-NBL1 mouse monoclonal antibody, clone AT38G8, Purified

Product Images

The cell lysate of Jurkat (30ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human NBL1 antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

Specifications

Product Data

• Clone Name: AT38G8
• Applications: ELISA, FC, IF, WB
• Recommended Dilution: ELISA.
  Flow Cytometry.
  Immunocytochemistry/Immunofluorescence.
  Western blot / Immunoblot.
  The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended starting dilution is 1:1000.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant human NBL1 (18-181aa) purified from E. coli
• Formulation: PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: 1.0 mg/ml
• Purification: Protein-A affinity chromatography
• Gene Name: Homo sapiens neuroblastoma 1, DAN family BMP antagonist (NBL1), transcript variant 2
• Database Link:
  Entrez Gene 100532736 Human
• Background: NBL1 is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development and alternatively spliced transcript variants have been identified for this gene. Also, as a tumor suppressor gene of neuroblastoma may play an important role in preventing cells from entering the final stage (G1/S) of the transformation process. Read-through transcripts between this locus and the upstream mitochondrial inner membrane organizing system 1 have been observed.
• Synonyms: DAN, DAND1

Reference Data

• Protein Families: Secreted Protein