HINT2 Mouse Monoclonal Antibody [Clone ID: AT5B10]
Other products for "HINT2"
Specifications
Product Data | |
Clone Name | AT5B10 |
Applications | ELISA, FC, WB |
Recommended Dilution | The antibody has been tested by ELISA, Western blot analysis and Flow cytometry to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. |
Reactivities | Human |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Recombinant human HINT2 (18-163aa) purified from E. coli. |
Formulation | Liquid. In Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol. State: Purified State: Liquid purified Ig fraction |
Concentration | 1.0 mg/ml |
Purification | Protein-A affinity chromatography |
Gene Name | Homo sapiens histidine triad nucleotide binding protein 2 (HINT2) |
Database Link | |
Background | Histidine triad nucleotide binding protein 2 (HINT2) is a mitochondrial protein. This protein is an AMP-lysine hydrolase and phosphoamidase and may contribute to tumor suppression. This protein is a member of the HIT superfamily and Hint subfamily, which are characterized as nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides. HINT2 regulates steroidogenesis through calcium-dependent and calcium-independent siglling pathways that may serve to maintain a favorable mitochondrial potential. Its role in calcium homeostasis may also contribute to its proapoptotic function in hepatocytes and other non-steroidogenic cells, though the exact mechanism remains unclear. |
Synonyms | HINT-2, HINT-3, HIT-17kDa, PKCI-1-related HIT protein |
Reference Data |
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