SIGLEC5 / SIGLEC14 Mouse Monoclonal Antibody [Clone ID: 1A5]

CAT#: AM60041FC-N

SIGLEC5 / SIGLEC14 mouse monoclonal antibody, clone 1A5, FITC, Purified


USD 415.00

5 Days*

Size
    • 100 ug

Product Images

Specifications

Product Data
Clone Name 1A5
Applications FC
Recommended Dilution Flow cytometry: Neat-1/10, use 10µl of this working dilution to label 10e6 cells in 100µl.
Reactivities Chimpanzee, Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen SIGLEC5-Fc protein, consisting of the full-length extracellular region of human SIGLEC5, fused with the Fc region of human IgG1
Specificity This antibody recognises human SIGLEC5 / CD170.  Clone 1A5 antibody is one of several SIGLEC5 antibodies which also recognises human SIGLEC14 (Angata, T. et al., 2006).
Formulation PBS containing 0.09% Sodium azide and 1% BSA
Label: FITC
State: Purified
State: Liquid purified IgG
Label: Fluorescein Isothiocyanate Isomer 1
Concentration 0.1 mg/ml
Purification Affinity chromatography on Protein G
Conjugation FITC
Background Siglec-5 shares an almost identical sequence with Siglec-14 within the first two Ig-like domains, indicating partial gene conversion between these two Siglecs, also evident in other primate species.
Siglec-5, also known as CD170, is a sialic-acid-binding Ig-like lectin, and member of the Ig superfamily, expressed by dendritic cells (DCs), activated macrophages, neutrophils, and cells of the monocyte/myeloid lineage. Highly related to the myelomonocytic-derived adhesion molecule CD33 (Siglec-3), Siglec-5 mediates sialic-acid dependent binding to cells, and is as well acting as an inhibitory receptor in the down-regulation of cell activation. Structurally, Siglec-5 contains an immunoreceptor tyrosine-based inhibitor motif (ITIM), which plays a part in the modulation of cellular responses, and when phosphorylated, can bind to the SH2 domain of several SH2-containing phosphatases.
Siglec-14 is a putative sialic-acid binding adhesion molecule and predominantly expressed in hematopoietic tissues, which have been shown to associate with the activating adapter protein DAP12.
Synonyms Q08ET2, O15389, CD170
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.