SIGLEC10 Mouse Monoclonal Antibody [Clone ID: 5G6]

CAT#: AM60044FC-N

SIGLEC10 mouse monoclonal antibody, clone 5G6, FITC, Purified


USD 415.00

5 Days*

Size
    • 100 ug

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Specifications

Product Data
Clone Name 5G6
Applications FC
Recommended Dilution Flow cytometry: Neat - 1/10, use 10ul of the suggested working dilution to label 10e6 cells.
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Recombinant human SIGLEC10, fused with the Fc region of human IgG
Specificity This antibody clone 5G6 specifically recognizes human SIGLEC10.
Studies have shown that clone 5G6 does not cross react with SIGLECs 3, 5, 7, 8 and 9 (Munday J. et al.)
Formulation PBS containing 0.09% Sodium azide and 1% BSA
Label: FITC
State: Purified
State: Liquid purified IgG
Label: Fluorescein Isothiocyanate Isomer 1
Concentration 0.1 mg/ml
Purification Affinity chromatography on Protein G
Conjugation FITC
Background Siglec10 (Sialic acid binding Ig like lectin 10), a putative adhesion molecule and member of the Ig superfamily, is expressed by monocytes, B cells, eosinophils, and at a higher level by a subpopulation of CD16+CD56- natural killer (NK) cells.
Structurally, Siglec10 is most similar to the CD33 related group of Siglecs, and preferentially binds to glycoconjugates containing alpha 2,3 or alpha2,6 linked sialic acid. Studies have shown that Siglec10 acts as a substrate for VAP1 (Vascular adhesion protein1), a glycoprotein expressed on endothelium during inflammation, which is involved in primary amine oxidation and leucocyte trafficking (Kive, E. et al.). This interaction between Siglec10 and VAP1, implicates Siglec10 in endothelial lymphocyte adhesion and in the modulation of the inflammatory microenvironment.
Synonyms Siglec-10, SLG2
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.