Hsc70 (HSPA8) Rabbit Polyclonal Antibody

CAT#: AP00035PU-N

Hsc70 (HSPA8) rabbit polyclonal antibody, Purified

Product Images

Western blot analysis of Hsc70 expression in Jurkat cell lysate (Lane 1) and mouse small intestine tissue lysate (Lane 2).

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western Blot: 0.5-4 μg/ml.
  Immunohistochemistry.
  Jurkat cell lysate and mouse small intestine lysate can be used as positive controls.
• Reactivities: Bovine, Hamster, Human, Monkey, Mouse, Porcine, Rat, Sheep
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide surrounding amino acid 559 of human Hsc70
• Specificity: The antibody detects a 71 kDa Hsc70. A ~40 kDa band can also be detected in human samples.
• Formulation: PBS, pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal
  State: Purified
  State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Affinity chromtography
• Storage: Store the antibody undiluted at -20°C or for long term storage (in aliquots) at -20°C to -70°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens heat shock protein family A (Hsp70) member 8 (HSPA8), transcript variant 1
• Database Link:
  Entrez Gene 15481 MouseEntrez Gene 24468 RatEntrez Gene 3312 Human
• Background: The 70 kDa heat shock cognate protein, Hsc70, is closely related to Hsp70 and is part of the Hsp70 family. The family contains a number of highly-related protein isoforms ranging in size from 66 kDa to 78 kDa. These proteins include both cognate members which are found within major intracellular compartments and highly inducible isoforms which appear to be predominantly cytoplasmic or nuclear in distribution. Members of the Hsp70 family are molecular chaperones which are involved in many cellular functions such as protein folding, transport, maturation and degradation and they exert their function in an AATP-dependent manner.
• Synonyms: HSP73, HSPA10, Heat shock cognate 71 kDa protein, Heat shock 70 kDa protein 8
• Note: Blocking peptide (AP00035CP-N) is also available.

Reference Data

• Protein Families: Stem cell - Pluripotency
• Protein Pathways: Antigen processing and presentation, Endocytosis, MAPK signaling pathway, Spliceosome