p38 (MAPK14) Rabbit Polyclonal Antibody

CAT#: AP00039PU-N

p38 (MAPK14) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of p38 MAP kinase in Jurkat cell lysate using antibody

Specifications

Product Data

• Applications: IHC, IP, WB
• Recommended Dilution: Western blotting (0.5-4.0 μg/ml).
  Immunoprecipitation (10-20 μg/ml).
  Immunohistochemistry (10-20 μg/ml).
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide mapping to the N-terminus of human p38 MAP kinase
• Specificity: The antibody detects p38 MAP kinase. It does not cross-react with either JNK/SAPK or p44/42 MAP kinase.
• Formulation: PBS containing 30 % glycerol, 0.5 % BSA, and 0.01 % thimerosal
  State: Aff - Purified
  State: Liquid affinity purified Ig fraction
• Concentration: lot specific
• Storage: Store undiluted (in aliquots) at -20°C to -70 °C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens mitogen-activated protein kinase 14 (MAPK14), transcript variant 1
• Database Link:
  Entrez Gene 26416 MouseEntrez Gene 81649 RatEntrez Gene 1432 Human
• Background: p38 MAP kinase is the mammalian homologue of the yeast HOG kinase and participates in a cascade controlling cell cellular responses to cytokines and stress. Like the SAPK/JNK pathway, p38 MAP kinase is activated by a variety of cellular stresses including inflammatory cytokines, UV light and growth factors, etc. Activated p38 MAP kinase has been shown to phosphorylate and activate MAPKAP kinase-2 and to phosphorylate the transcription factors ATF-2 and Max.
• Synonyms: Mitogen-activated protein kinase 14, p38 alpha, MXI2, SAPK2A, CSBP, CSBP1, CSBP2, CSPB1
• Note: Blocking peptide (Cat. no. AP00039CP-N) is available separately.

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Amyotrophic lateral sclerosis (ALS), Epithelial cell signaling in Helicobacter pylori infection, Fc epsilon RI signaling pathway, GnRH signaling pathway, Leukocyte transendothelial migration, MAPK signaling pathway, Neurotrophin signaling pathway, NOD-like receptor signaling pathway, Progesterone-mediated oocyte maturation, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, Toll-like receptor signaling pathway, VEGF signaling pathway