p38 (MAPK14) pThr180/pTyr182 Rabbit Polyclonal Antibody

CAT#: AP00176PU-N

p38 (MAPK14) pThr180/pTyr182 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of extracts from 0.5 hr (Left lane) and 1 hr (right lane) UV treated 3T3 cells.

Specifications

Product Data

• Applications: IHC, IP, WB
• Recommended Dilution: Western Blot: 0.5-4 μg/ml.
  Immunoprecipitation: 10-20 mg/ml.
  Immunohistochemistry: 10-20 mg/ml.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic phospho-peptide surrounding amino acid Thr180/Tyr182 of human p38 MAP kinase.
• Specificity: The antibody recognizes 43 kDa phosphorylated p38 (Thr180/Tyr182) MAP kinase
• Formulation: PBS containing 50% Glycerol, 1% BSA as stabilizer and 0.02 % Thimerosal as preservative.
  State: Aff - Purified
  State: Liquid purified Ig fraction.
• Concentration: lot specific
• Purification: Affinity Chromatography.
• Storage: Store the antibody undiluted at -20°C or for long term storage (in aliquots) at -70°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens mitogen-activated protein kinase 14 (MAPK14), transcript variant 1
• Database Link:
  Entrez Gene 26416 MouseEntrez Gene 81649 RatEntrez Gene 1432 Human
• Background: p38 MAP kinase is the mammalian homologue of the yeast HOG kinase and participates in a cascade controlling cellular responses to cytokines and stress. Like the SAPK/JNK pathway, p38 MAP kinase is activated by a variety of cellular stresses including inflammatory cytokines, UV light and growth factors, etc. Activated p38 MAP kinase has been shown to phosphorylate and activate MAPKAP kinase-2 and to phosphorylate the transcription factors ATF-2 and Max.
• Synonyms: Mitogen-activated protein kinase 14, p38 alpha, MXI2, SAPK2A, CSBP, CSBP1, CSBP2, CSPB1

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Amyotrophic lateral sclerosis (ALS), Epithelial cell signaling in Helicobacter pylori infection, Fc epsilon RI signaling pathway, GnRH signaling pathway, Leukocyte transendothelial migration, MAPK signaling pathway, Neurotrophin signaling pathway, NOD-like receptor signaling pathway, Progesterone-mediated oocyte maturation, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, Toll-like receptor signaling pathway, VEGF signaling pathway