Phospholipase C gamma 1 (PLCG1) Rabbit Polyclonal Antibody

CAT#: AP00342PU-N

Phospholipase C gamma 1 (PLCG1) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of PLC? 1&2 expression in Jurkat cell lysate.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western Blot: 0.5-4 μg/ml; Jurkat cell lysate can be used as a positive control.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide surrounding amino acid 1252 of human PLCγ2
• Specificity: The antibody recognizes 139 kDa human PLCγ 1&2.
• Formulation: PBS containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal
  State: Aff - Purified
  State: Liquid purified Ig
• Concentration: lot specific
• Purification: Protein A affinity purified
• Storage: Store the antibody undiluted at -20°C or for long term storage (in aliquots) at -70°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens phospholipase C gamma 1 (PLCG1), transcript variant 2
• Database Link:
  Entrez Gene 5335 Human
• Background: PLC (Phosphoinositide-specific phospholipase C) plays a significant role in transmembrane signaling. Four members of PLCs have been identified: PLCβ, PLCγ, PLCδ, and PLCε. In response to extracellular stimuli (e.g., hormone, growth factors, neurotransmitters), PLC hydrolizes phosphatidylinositol 4,5-biphosphate (PIP2) into two secondary messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PLCγ2 is engaged in antigendependent signaling in B-cells and collagen-dependent signaling in platelets.
• Synonyms: PLC-148, PLC-II, PLC-gamma-1, PLC1, PLCG-1, Phospholipase C-gamma-1, Phospholipase C-gamma-2, PLC-gamma-2, PLCgamma2, PLCG-2, PLC-IV
• Note: Blocking peptide (AP00342CP-N) is available separately.

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Calcium signaling pathway, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Glioma, Inositol phosphate metabolism, Leukocyte transendothelial migration, Metabolic pathways, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Non-small cell lung cancer, Pathways in cancer, Phosphatidylinositol signaling system, T cell receptor signaling pathway, VEGF signaling pathway, Vibrio cholerae infection