Factor IX (F9) Sheep Polyclonal Antibody

CAT#: AP00715PU-N

Factor IX (F9) sheep polyclonal antibody, Purified

Specifications

Product Data

• Applications: ELISA, WB
• Recommended Dilution: ELISA: 1/50,000.
  Western blot: 1-5 µg/ml.
• Reactivities: Mouse
• Host: Sheep
• Clonality: Polyclonal
• Immunogen: Mouse Factor IX
• Specificity: This antibody recognizes Factor IX and Factor IX alpha.
• Formulation: 0.05 M Sodium Phosphate, pH 6.6 containing 0.1 M Sodium Chloride and 1 mM EDTA without preservatives.
  State: Purified
  State: Liquid purified Ig fraction.
• Concentration: lot specific
• Purification: Protein G Chromatography
• Storage: Store the antibody at -70°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Background: Factor IX circulates in the blood as an inactive zymogen at the normal concentration of approximately 3 µg/ml. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca2+ ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X linked disorder, also called hemophilia B or Christmas disease. The disease affects approximately 1 in 50,000 of the population (almost exclusively males).
• Synonyms: Christmas factor, PTC