CLN6 Rabbit Polyclonal Antibody

CAT#: AP01390PU-N

CLN6 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of CLN6 antibody (Cat.-No.: AP01390PU-N) in extracts from HeLa cells.

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  Immunohistochemistry (IHC) analyzes of CLN6 antibody (Cat.-No.: AP01390PU-N) in paraffin-embedded human cervix carcinoma tissue.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western Blot: 1/500-1/1000.
  Immunohistochemistry on paraffin sections: 1/50-1/200.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: CLN6 antibody detects endogenous levels of CLN6 protein. (region surrounding asn258)
• Formulation: Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography
• Predicted Protein Size: ~ 40 kDa
• Gene Name: Homo sapiens ceroid-lipofuscinosis, neuronal 6, late infantile, variant (CLN6)
• Database Link:
  Entrez Gene 54982 Human
• Background: CLN6, a 311-amino acid protein, has 7 predicted transmembrane domains and is conserved across vertebrates. The CLN6 protein localizes to the endoplasmic reticulum but contributes to lysosomal function. Mutations in the CLN6 gene cause variant late-onset infantile neuronal ceroid lipofuscinosis (vLINCL), a lysosomal storage disorder marked by progressive mental deterioration and blindness; part of a group of severe inherited neurodegenerative disorders affecting children wherein lysosomes accumulate storage material, causing the death of neurons. CLN6 is one of eight proteins, including CLN1-8, that are associated with NCL.
• Synonyms: FLJ20561; HsT18960; nclf

Reference Data

• Protein Families: Transmembrane