CLCN6 Rabbit Polyclonal Antibody

CAT#: AP01392PU-N

CLCN6 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of CLC-6 antibody (Cat.-No.: AP01392PU-N) in extracts from HT-29 cells.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western Blot: 1/500-1/1000.
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: CLC-6 antibody detects endogenous levels of CLC-6 protein. (region surrounding Lys649)
• Formulation: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 90 kDa
• Gene Name: Homo sapiens chloride voltage-gated channel 6 (CLCN6), transcript variant 1
• Database Link:
  Entrez Gene 26372 MouseEntrez Gene 1185 Human
• Background: The family of voltage-dependent chloride channels (CLCs) regulate cellular trafficking of chloride ions, a critical component of all living cells. CLCs regulate excitability in muscle and nerve cells, aid in organic solute transport and maintain cellular volume. The genes encoding human CLC-1 through CLC-7 map to chromosomes 7, 3q26, 4q32, Xp22, Xp11, 1p36 and 16p13, respectively. CLC-1 is highly expressed in skeletal muscle. Mutations in the gene encoding CLC-1 lead to myotonia, an inheritable disorder characterized by muscle stiffness and renal salt wasting. CLC-2 is highly expressed in the epithelia of several organs including lung, which suggests CLC-2 may be a possible therapeutic target for cystic fibrosis. CLC-3 expression is particularly abundant in neuronal tissue, while CLC-4 expression is evident in skeletal and cardiac muscle as well as brain. Mutations in the gene encoding CLC-5 lead to Dent’s disease, a renal disorder characterized by proteinuria and hypercalciuria. CLC-6 and CLC-7 are broadly expressed in several tissues including testes, kidney, brain and muscle.
• Synonyms: Chloride channel protein 6, ClC-6, ClC6, KIAA0046

Reference Data

• Protein Families: Druggable Genome, Ion Channels: Other, Transmembrane