DNAJB11 Rabbit Polyclonal Antibody

CAT#: AP01395PU-N

DNAJB11 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of ERdj3 antibody (Cat.-No.: AP01395PU-N) in extracts from HeLa cells.

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  Immunohistochemistry (IHC) analyzes of ERdj3 antibody (Cat.-No.: AP01395PU-N) in paraffin-embedded human heart tissue.

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: Western Blot: 1/500-1/1000.
  Immunohistochemistry on paraffin sections: 1/50-1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: ERdj3 antibody detects endogenous levels of ERdj3 protein. (region surrounding Lys66)
• Formulation: Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography
• Predicted Protein Size: ~ 40 kDa
• Gene Name: Homo sapiens DnaJ heat shock protein family (Hsp40) member B11 (DNAJB11)
• Database Link:
  Entrez Gene 67838 MouseEntrez Gene 360734 RatEntrez Gene 51726 Human
• Background: Members of the heat shock protein 40 (HSP 40) family of proteins all contain a highly conserved J domain that associates with HSP 70 and regulates the function of HSP 70 by activating its adenosine triphosphatase activity. ERdj3, an HSP 40 chaperone, is expressed in the ER lumen, where it interacts with BiP, a molecule involved in retrotranslocating proteins out of the ER. ERdj3 also associates with several other protein substrates, including unfolded light chains, a nonsecreted Ig light chain mutant and a VSV-G ts045 mutant. Shiga toxin (Stx) is a bacterial tool that enzymatically inactivates the 28S rRNA, inhibiting protein synthesis of infected cells. Stx also interacts with ERdj3 and Sec 61 to form a complex through which proteins are retrotranslocated to the cytoplasm. ERdj3 may play a role in the ER quality control system.
• Synonyms: EDJ, ERJ3, PSEC0121, ERj3p, ERdj3, HEDJ, hDj9, PWP1-interacting protein 4, APOBEC1-binding protein 2

Reference Data

• Protein Families: Transmembrane