Chk1 (CHEK1) Sheep Polyclonal Antibody
Specifications
Product Data | |
Applications | IP, WB |
Recommended Dilution | Western Blot: 1-10 µg/ml. Immunoprecipitation. |
Reactivities | Human, Monkey, Mouse, Rat |
Host | Sheep |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | A GST fusion protein corresponding to amino acid sequence 1-474 with having a molecular weight of 54 kD. |
Specificity | This antibody recognizes CHK1 kinase. |
Formulation | Phosphate buffered saline with 0.08% Sodium Azide as preservative. State: Purified State: Liquid (0.2µm sterile filtered) purified IgG fraction. |
Concentration | Lot specific |
Database Link | |
Background | One mechanism by which checkpoints maintain the fidelity of cell cycle events is through blocking mitosis in response to unreplicated or damaged DNA. In most species this occurs through inhibiting activation of the cyclic-dependent kinase cdc2, which regulates entry in to mitosis. Chk1, a kinase involved in the DNA damage checkpoint response can phosphorylate Cdc25C an activator of cdc2. It is hypothesized that chk 1 induces serine 216 phosphorylation of Cdc 25C and subsequent binding negatively regulated Cdc25C, thus preventing it from activating cdc2. |
Synonyms | CHEK1, CHEK-1 |
Reference Data |
Documents
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