Chk1 (CHEK1) Sheep Polyclonal Antibody

CAT#: AP05017PU-N

Chk1 (CHEK1) sheep polyclonal antibody, Purified


USD 360.00

5 Days*

Size
    • 250 ug

Product Images

Specifications

Product Data
Applications IP, WB
Recommended Dilution Western Blot: 1-10 µg/ml.
Immunoprecipitation.
Reactivities Human, Monkey, Mouse, Rat
Host Sheep
Isotype IgG
Clonality Polyclonal
Immunogen A GST fusion protein corresponding to amino acid sequence 1-474 with having a molecular weight of 54 kD.
Specificity This antibody recognizes CHK1 kinase.
Formulation Phosphate buffered saline with 0.08% Sodium Azide as preservative.
State: Purified
State: Liquid (0.2µm sterile filtered) purified IgG fraction.
Concentration Lot specific
Background One mechanism by which checkpoints maintain the fidelity of cell cycle events is through blocking mitosis in response to unreplicated or damaged DNA. In most species this occurs through inhibiting activation of the cyclic-dependent kinase cdc2, which regulates entry in to mitosis. Chk1, a kinase involved in the DNA damage checkpoint response can phosphorylate Cdc25C an activator of cdc2. It is hypothesized that chk 1 induces serine 216 phosphorylation of Cdc 25C and subsequent binding negatively regulated Cdc25C, thus preventing it from activating cdc2.
Synonyms CHEK1, CHEK-1
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.