MAGI3 (GKWW domain) Sheep Polyclonal Antibody

CAT#: AP05020PU-N

MAGI3 (GKWW domain) sheep polyclonal antibody, Purified

Product Images

Western blot analysis using MAGI-3, GKWW antibody on cell lysates transfected with full-length human MAGI-3 protein.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western Blot: 1 - 10 µg/ml. Detects a 130 kDa band in cells transfected with full-length MAGI-3 protein.
• Reactivities: Human
• Host: Sheep
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein corresponding to the guanylate kinase-WW domain of MAGI-3.
• Specificity: This antibody reacts to MAGI-3, GKWW.
• Formulation: Phosphate buffered saline with 0.08% sodium azide
  State: Purified
  State: Liquid purified Ig (0.2 µm sterile filtered)
• Concentration: Lot specific
• Gene Name: Homo sapiens membrane associated guanylate kinase, WW and PDZ domain containing 3 (MAGI3), transcript variant 1
• Database Link:
  Entrez Gene 260425 Human
• Background: Membrane-associated guanylate kinase with inverted orientation (MAGI3) is a novel, 130 kDa guanylate kinase which is part of a family of multi-PDZ domain containing guanylate kinases. These guanylate kinases are localized to epithelial cell tight junctions. MAGI3 and PTEN/MMAC cooperate to modulate the kinase activity of AKT/protein kinase B (PKB). MAGI3 positions the PTEN/MMAC phosphatase to specific subcellular locations that are involved with the regulation of cell proliferation and survival. MAGI3, as well as other proteins in this family, are made up of an N-terminal guanylate kinase domain, followed by a WW domain, named for two conserved tryptophan residues and first identified as two repeats in mouse YAP65, which is them followed by 5 PDZ domains.
• Synonyms: MAGI-3

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Tight junction