VAV2 (SHD Region) Sheep Polyclonal Antibody

CAT#: AP05063PU-N

VAV2 (SHD Region) sheep polyclonal antibody, Purified


USD 360.00

5 Days*

Size
    • 250 ug

Product Images

Specifications

Product Data
Applications IP, WB
Recommended Dilution Western Blot: 1:5,000.
Immunoprecipitation.
Reactivities Human
Host Sheep
Isotype IgG
Clonality Polyclonal
Immunogen A his tagged fusion protein Vav-2 corresponding to amino acid sequence
Specificity This antibody reacts to Vav-2 SHD.
Formulation Phosphate buffered saline with 0.08% sodium azide
State: Purified
State: Liquid purified Ig (0.2 µm sterile filtered)
Concentration Lot specific
Background The immunogen used for the anti-human Vav-2 SHD region was a his tagged fusion protein Vav-2 corresponding to amino acid sequence 578 - 878 and having a molecular weight of 100kD. Vav-2 has a molecular weight of 100 kD and shares over a 50% homology at the amino acid and nucleic acid level with Vav. Vav-2 is a ubiquitously expressed structural homolog of the Vav protooncogene that is expressed preferentially in hematopoetic cells. Both proteins are comprised of a Dbl- homology (DH) domain with guanosine nucleotide exchange (GEF) activity exclusively directed towards Rho/Rac GTPases, a pleckstrin homology (PH) domain, a calponin-homology (CH) region, an acidic domain (AD) a zinc finger butterfly motif, two SH3 regions and one SH2 domain. GEF activity of RhoA family G proteins is induced by tyrosine phosphorylation in wild type vav-2, and is constitutively activated in N terminus deleted oncogene forms. Constitutive expression of a Vav-2 oncoprotein may result in morphological alterations including highly enlarged cells in which karyokinesis and cytokinesis frequently are uncoupled.
Synonyms VAV-2
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.