VAV2 (DPH Region) Sheep Polyclonal Antibody

CAT#: AP05064PU-N

VAV2 (DPH Region) sheep polyclonal antibody, Purified


USD 360.00

5 Days*

Size
    • 250 ug

Product Images

Specifications

Product Data
Applications IP, WB
Recommended Dilution Western Blot: 1/5,000.
Immunoprecipitation (Empirical).
Reactivities Human
Host Sheep
Isotype IgG
Clonality Polyclonal
Immunogen A his tagged fusion protein Vav-2 corresponding to amino acid sequence 287-578 and having a Molecular Weight of 100kD
Specificity This antibody reacts to Vav-2 DPH.
Formulation PBS with 0.08% Sodium Azide as preservative
State: Purified
State: Liquid (0.2 µm sterile filtered) purified Ig fraction
Concentration Lot specific
Purification Ammonium Sulfate Precipitation
Background Vav-2 has a molecular weight of 100 kD and shares over a 50% homology at the amino acid and nucleic acid level with Vav. Vav-2 is a ubiquitously expressed structural homolog of the Vav protooncogene that is expressed preferentially in hematopoetiic cells. Both proteins are comprised of a Dbl- homology ((DH) domain with guanosine nucleotide exchange (GEF) activity exclusively directed towards Rho/Rac GTPases, a pleckstrin homology (PH) domain, a calponin-homology (CH) region, an acidic domain (AD) a zinc finger butterfly motif, two SH3 regions and one SH2 domain. GEF activity of RhoA family G proteins is induced by tyrosine phosphorylation in wild type vav-2, and is constitutively activated in N terminus deleted oncogene forms. Constitutive expression of a Vav-2 oncoprotein may result in morphological alterations including highly enlarged cells in which karyokinesis and cytokenesis frequently are uncoupled.
Synonyms VAV-2
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.