Dab1 (C-term) Sheep Polyclonal Antibody

CAT#: AP05071PU-N

Dab1 (C-term) sheep polyclonal antibody, Purified

Product Images

Western blot analysis using Disabled-1 (NT) (1) and (CT) (2) on mouse brain extracts.

Specifications

Product Data

• Applications: IP, WB
• Recommended Dilution: Western Blot: 1 μg/ml.
  Immunoprecipitation: 5 μg/ml.
  POSITIVE CONTROL: 293 cells transfected with Dab-1-HA tag.
• Reactivities: Mouse
• Host: Sheep
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein corresponding to amino acids 399 - 555 of mouse disabled coupled to a GST fusion protein.
• Specificity: This antibody reacts to DAB1 (Disabled 1) (C Terminal).
• Formulation: Phosphate buffered saline with 0.08% sodium azide
  State: Purified
  State: Liquid purified Ig (0.2µm sterile filtered)
• Concentration: Lot specific
• Gene Name: Mus musculus disabled 1 (Dab1), transcript variant 1
• Database Link:
  Entrez Gene 13131 Mouse
• Background: Disruption of the disabled-1 gene (Dab1) results in aberrant migration of neurons during development and disorganization of laminar structures throughout the brain. Dab1 is thought to function as an adaptor molecule in signal transduction processes. It contains a protein-protein interaction (PI) similar to the phosphotyrosine binding domain of the Shc oncoprotein, it is phosphorylated by the Src protein tyrosine kinase, and it binds to SH2 binding domains in a phosphotyrosine dependent manner. Disabled-1 acts downstream of reelin in a signalling pathway.
• Synonyms: Disabled homolog 1