DYRK Sheep Polyclonal Antibody

CAT#: AP05079PU-N

DYRK sheep polyclonal antibody, Purified

Product Images

Figure 1. Immunoprecipitation of Dyrk from 293T transfected cells. Immunoprecipitation with: 1. Control Ab 2. Anti-MNP 2 g/ml 3. anti-Dyrk 2 g/ml 4. anti-Dyrk 10 g/ml 5. Competitor's anti-Dyrk Ab 10 g/ml, Western blot performed with anti-Dyrk Ab at 2 g/ml.

Specifications

Product Data

• Applications: IP, WB
• Recommended Dilution: Western Blot: 1 µg/ml.
  Immunoprecipitation.
  Immunofluoresecence: 1-10 µg/ml.
• Reactivities: Human, Mouse, Rat
• Host: Sheep
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein corresponding to amino acids 486 to 763 of the Mouse Dyrk1A protein.
• Specificity: This antibody recognizes DYRK.
• Formulation: Phosphate buffered saline with 0.08% Sodium Azide as preservative.
  State: Purified
  State: Liquid purified Ig (0.2 µm sterile filtered)
• Concentration: 1.0 mg/ml
• Background: Dyrk, the vertebrate of Drosophilia minibrain, is a dual-specificity kinase predominately expressed in the central nervous system. The human clone has been isolated from the Downs' syndrome critical region and it is potentially implicated in the neuropathology of the disease. Main features of the protein include an N-terminal nuclear translocation signal, a putative leucine zipper domain, a core kinase domain with some similarity to kinases involved in cell cycle regulation and a C-terminal PEST sequence. The Dyrk kinase can be phosphorylated on tyrosine residues, leading to an active kinase that can phosphorylated itself or exogenous substrates on both tyrosine and serine/threonine residues. Dyrk can also multimerize and translocate to the nucleus. Present studies on Dyrk suggest a potential role for this kinase in the exit from the cell cycle and the beginning of neuronal differentiation.
• Synonyms: DYRK1A, MNB, MNBH, Dual specificity YAK1-related kinase