BubR1 (BUB1B) Sheep Polyclonal Antibody

CAT#: AP05109PU-N

BubR1 (BUB1B) sheep polyclonal antibody, Purified


USD 360.00

5 Days*

Size
    • 250 ug

Product Images

Specifications

Product Data
Applications IHC, WB
Recommended Dilution Western Blot: 1 - 10 µg/ml; Detects a 130 kDa band.
Immunohistochemistry.
Reactivities Mouse
Host Sheep
Isotype IgG
Clonality Polyclonal
Immunogen Recombinant protein corresponding to amino acids 232 - 603 of the mouse Bub1b protein.
Specificity This antibody reacts to Bub1b.
Formulation Phosphate buffered saline with 0.08% sodium azide
State: Purified
State: Liquid purified Ig
Concentration lot specific
Storage The antibody can be shipped at ambient temperature. Store (in aliquots) at -20°C only.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Background Bub1, a mitotic checkpoint gene first identified in yeast, ensures proper chromosome segregation by delaying anaphase until chromosomes are properly aligned on the mitotic spindle. Mutations in the mitotic spindle assembly checkpoint genes, like yeast Bub1, cause cells to exit mitosis without proper chromosome attachment/alignment, resulting in aneuploidy. Aneuploidy is a form of genetic instability involved in cancer. Recently, a novel homologue of the murine Bub1 gene has been identified and named Bub1b. The yeast mitotic checkpoint pathway is unresolved, but the mammalian pathway remains even less clear. It is important to investigate the role of the Bub1 genes in the mammalian checkpoint as they have been implicated in carcinogenesis, namely colon carcinomas. The aneuploidy and chromosome instability characterizing some tumors is thought to be caused by mutations in Bub1.
Synonyms Protein SSK1, BUBR1, MAD3L, BUB1 beta
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.