Cortisol Sheep Polyclonal Antibody

CAT#: AP05396PU-N

Cortisol sheep polyclonal antibody, Ig Fraction

Specifications

Product Data

• Applications: ELISA
• Recommended Dilution: ELISA (1/500-1/2500 as a recommended dilution).
• Reactivities: Broad
• Host: Sheep
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Cortisol-21-hemisuccinyl-KLH/BSA/Fetuin mixture.
• Specificity: This anitbody recognizes the Glucocorticoid Hormone Cortisol, produced in the adrenal cortex and involved in responses to stress.
  The following cross reactivities have been observed:
  Cortisol: 100%
  Corticosterone: > 90%
• Formulation: PBS, pH 7.2 containing 0.09% Sodium Azide
  State: Ig Fraction
  State: Liquid purified IgG fraction
• Concentration: ~5.0 mg/ml
• Purification: Affinity Chromatography
• Background: Cortisol is the most potent glucocorticoid produced by the human adrenal.
  It is synthesized from cholesterol and its production is stimulated by pituitary adrenocorticotropic hormone (ACTH) which is regulated by corticotropin releasing factor (CRF). ACTH and CRF secretions are inhibited by high cortisol levels in a negative feedback loop. In plasma a majority of cortisol is bound with high affinity to corticosteroid binding globulin (CBG or transcotin). Cortisol acts through specific intracellular receptors and affects numerous physiologic systems including immune function, glucose counter regulation, vascular tone, and bone metabolism.
• Synonyms: Hydrocortisone