SRD5A2 (C-term) Rabbit Polyclonal Antibody
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Specifications
Product Data | |
Recommended Dilution | Immunohistochemistry on Paraffin Sections (Heat induced epitope retrieval is required). Positive Control: Rat Prostate. |
Reactivities | Human, Rat |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | Synthetic peptide corresponding to a C-terminal portion of native Rat 5-Alpha Reductase type 2 conjugated to Human Thyroglobulin. |
Specificity | This antibody is specific for 5-Alpha Rreductase type 2 and does not react with 5-Alpha Reductase type 1. |
Formulation | Ammonium Bicarbonate State: Purified State: Lyophilized purified Ig fraction Stabilizer: None Preservative: None |
Reconstitution Method | Restore in 50 µl of sterile distilled water. Addition of Sodium Azide is recommended for long term storage. |
Purification | Ammonium Sulphate Precipitation |
Storage | Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Gene Name | Homo sapiens steroid 5 alpha-reductase 2 (SRD5A2) |
Database Link | |
Background | SRD5A2 (Steroid-5-alpha-reductase, alpha polypeptide 2) is a microsomal protein. It converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology. |
Synonyms | SRD5A2, 3-oxo-5-alpha-steroid 4-dehydrogenase 2, EC=1.3.99.5, Steroid 5-alpha-reductase 2, 5 alpha-SR2, Type II 5-alpha reductase, SR type 2 |
Reference Data | |
Protein Families | Druggable Genome, Transmembrane |
Protein Pathways | Androgen and estrogen metabolism, Prostate cancer |
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