CTC_RS14060 Goat Polyclonal Antibody

CAT#: AP05529PU-N

CTC_RS14060 goat polyclonal antibody, Purified

Specifications

Product Data

• Applications: ELISA, WB
• Recommended Dilution: ELISA: 1 µg/ml.
  Western Blot: 1/100-1/500.
• Host: Goat
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Tetanus Exotoxin
• Specificity: This antibody detects the tetanus toxin which is produced by the soil micro-organism Clostridium tetani. C. tetani infection results in its systemic growth and secretion of tetanus, which causes muscle spasms by inhibiting neurotransmitter release.
  The antibody also reacts with the C-fragment (~50 kDa carboxy terminal residues 865-1315) of tetanus toxin (Emsley et al. 2000).
• Formulation: PBS pH 7.2
  State: Purified
  State: Liquid purified IgG fraction
  Preservative: 0.09% Sodium Azide
• Concentration: 5.0 mg/ml
• Purification: Affinity Chromatography
• Background: Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the 76-Gln-|-Phe-77 bond of synaptobrevin-2.
  The precursor polypeptide is subsequently cleaved to yield subchains L and H. These remain linked by a disulfide bridge and are non-toxic after separation.
• Synonyms: Clostridium tetani toxin, tetX