IFNAR1 Rabbit Polyclonal Antibody

CAT#: AP06615PU-N

IFNAR1 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of IFN-R1 antibody at 1/500 dilution Lane 1:HEK293T whole cell lysate Lane 2:Raw264.7 whole cell lysate Lane 3:H9C2 whole cell lysate

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  Immunohistochemistry (IHC) analyzes of IFN-a/βRa antibody in paraffin-embedded human brain tissue.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: Immunohistochemistry on paraffin sections: 1/50-1/200.
  Immunofluorescence: 1/50-1/200.
  Western blot: 1/500-1/1000.
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to amino acids 410-460 of Human IFN-R1.
• Specificity: This antibody detects endogenous levels of IFN-α/βRα protein.
  (region surrounding Leu461)
• Formulation: Phosphate buffered saline (PBS), pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 50 kDa
• Gene Name: Homo sapiens interferon alpha and beta receptor subunit 1 (IFNAR1)
• Database Link:
  Entrez Gene 3454 Human
• Background: The type I interferons, IFN-α and IFN-β, are a group of structurally and functionally related proteins that are induced by either viruses or double-stranded RNA and are defined by their ability to confer an antiviral state in cells. IFN-α and IFN-β appear to compete with one another for binding to a common cell surface receptor, while immune IFN (IFN-γ) binds to a distinct receptor. This distinct receptor, IFN-αR, is only weakly responsive to type I interferons, in contrast to IFN-α/βR, which binds to and responds effectively to IFN-β and to several of the IFN-α subtypes. IFN-α/βR is expressed as two alternatively spliced transcripts, designated IFN-α/βRα (IFN-α/βR1) and IFN-α/βRβ (IFN- α/βR2), both of which are involved in signal transduction and ligand binding.
• Synonyms: IFN-R-1, IFN-alpha Receptor alpha, IFN-alpha/beta receptor 1, Type I interferon receptor 1, CRF2-1

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity, Toll-like receptor signaling pathway