DKK1 (C-term) Goat Polyclonal Antibody

CAT#: AP07519PU-N

DKK1 (C-term) goat polyclonal antibody, Aff - Purified

Product Images

Placenta: Formalin-Fixed Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA: 1/128000.
  Immunohistochemistry on Paraffin Sections: 10 µg/ml.
  Western Blot: 1 - 3 µg/ml.
• Reactivities: Bovine, Canine, Equine, Goat, Human, Monkey, Mouse, Porcine
• Host: Goat
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from the C-terminus of human DKK1 (NP_036374.1)
• Specificity: This antibody reacts with C Terminus of DKK1.
• Formulation: Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: 0.5 mg/ml
• Purification: Immunoaffinity Chromatography
• Database Link:
  Entrez Gene 22943 Human
• Background: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
• Synonyms: DKK1, DKK-1, Dickkopf-related protein 1, SK