Thymidylate Synthase (TYMS) Sheep Polyclonal Antibody
Specifications
Product Data | |
Applications | ELISA, IF, IHC, IP, WB |
Recommended Dilution | ELISA. Immunofluorescence. Immunohistochemistry on Paraffin Sections: 5 µg/ml. Immunoprecipitation. Western Blot. |
Reactivities | Human |
Host | Sheep |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | Recombinant human Thymidylate Synthase (36 kD) produced in E. coli |
Specificity | This antibody recognizes Human Thymidylate Synthetase (TYMS). |
Formulation | 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2, 0.01% Sodium Azide as preservative State: Purified State: Liquid purified Ig fraction |
Concentration | lot specific |
Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Database Link | |
Background | Thymidylate synthase (TS) is an intracellular enzyme critical for de novo synthesis of DNA. In cancer, expression of TS is often elevated and becomes further elevated as a result of treatment with the most commonly used chemotherapeutic, 5-fluorouracil (5-FU). Resistance or lack of response to 5-FU is attributed to the elevation of TS activity. Overexpression of TS has been demonstrated in many types of tumors including breast, colon, gastric and melanoma and is usually predictive of shortened survival time. |
Synonyms | TYMS, TSase, OK/SW-cl.29 |
Reference Data |
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