Ionotropic Glutamate receptor 2 (GRIA2) (+ GLUR3) Rabbit Polyclonal Antibody

CAT#: AP08678PU-N

Ionotropic Glutamate receptor 2 (GRIA2) (+ GLUR3) rabbit polyclonal antibody, Aff - Purified

Product Images

Figure 1. Western blot of rat Hippocampal lysate showing specific immunolabeling of the ~100k GluR2/3 protein.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 1/1000.
• Reactivities: Chicken, Human, Mouse, Rat, Zebrafish
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Peptide corresponding to amino acid residues from the C-terminal region of rat GluR2/3.
• Specificity: This antibody is specific for endogenous levels of the ~100 kDa GluR2/3 protein.
• Formulation: 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% Glycerol.
  State: Aff - Purified
  State: Liquid purified Ig fraction.
• Purification: Affinity Chromatography.
• Storage: Store the antibody undiluted (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens glutamate ionotropic receptor AMPA type subunit 2 (GRIA2), transcript variant 1
• Database Link:
  Entrez Gene 14800 MouseEntrez Gene 29627 RatEntrez Gene 2891 Human
• Background: The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by -amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct glutamate receptor subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain (Keinänen et al., 1990;Hollmann and Heinemann, 1994). The GluR2 subunit is widely expressed throughout the nervous system where it is thought to play key roles in synaptic plasticity and learning and memory (Duprat et al., 2003;Seidenman et al., 2003;Chung et al., 2003;Yan et al., 2002).
• Synonyms: GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA2, GRIA2

Reference Data

• Protein Families: Druggable Genome, Ion Channels: Glutamate Receptors, Transmembrane
• Protein Pathways: Amyotrophic lateral sclerosis (ALS), Long-term depression, Long-term potentiation, Neuroactive ligand-receptor interaction