Gastrin (GAST) Rabbit Polyclonal Antibody
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Other products for "GAST"
Specifications
Product Data | |
Applications | IF, IHC |
Recommended Dilution | Immunocytochemistry. Immunohistochemistry on Frozen Sections. Immunohistochemistry on Paraffin Embedded Sections: No proteolytic treatment required. Recommended Dilutions: 1/50-1/100. Incubation Time: 1 h at room temperature or overnight at 2-8°C. |
Reactivities | Human, Mammalian |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Human gastrin 17 conjugated to BSA |
Specificity | Gastrin-secreting cells are numerous in the antrum and a few are found in the proximal duodenum. The antibody can be used for the diagnosis of gastrin-producing tumors which are mainly found in the pancreas and occasionally in the stomach and the duodenum. |
Formulation | PBS State: Serum State: Liquid Serum Stabilizer: 1% BSA Preservative: 0.09% Sodium Azide |
Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Gene Name | Homo sapiens gastrin (GAST) |
Database Link | |
Background | Gastrin is mainly known by its first described role as a gastric acid-hormone but the protein also has the ability to promote cellular growth. More recently, gastrin has been suggested to induce leukocyte-endothelial cell interactions and to have a pro-inflammatory effect. Gastrin has two biologically active peptide forms, G34 and G17 and they activate two different receptors: the CCK-1 receptor, which has low affinity for gastrin but high affinity for the related hormone cholecystokinin (CCK), and the CCK-2 receptor, which has high affinity for both gastrin and CCK and mediates the acid-secretory as well as the proliferative effects of gastrin. |
Synonyms | GAST, GAS |
Reference Data | |
Protein Families | Druggable Genome, Secreted Protein |
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