Gestrinone Sheep Polyclonal Antibody

CAT#: AP09728PU-L

Gestrinone sheep polyclonal antibody, Ig Fraction


USD 3,690.00

2 Weeks*

Size
    • 1 ml

Product Images

Specifications

Product Data
Applications ELISA
Recommended Dilution ELISA: 0.039 µg/ml.
Host Sheep
Isotype IgG
Clonality Polyclonal
Immunogen Gestrinone-BTG
Specificity This antibody recognizes Gestrinone.
Formulation 20mM Phosphate, 150mM Sodium Chloride, pH 7.2 containing 0.09% Sodium Azide as preservative.
State: Ig Fraction
State: Liquid Ig fraction prepared by Caprylic Acid and Ammonium Sulphate precipitation procedures.
Concentration 10.20 mg/ml (U.V.abs @ 280nm)
Background Endometriosis is common disease characterized by the presence of endometrial tissue outside the uterus which affects approximately 10% of premenopausal women. Gestrinone is a synthetic steroid used occasionally to treat endometriosis.(1) It acts centrally on the hypothalamic-pituitary system to suppress release of lutenizing hormone (LH) and follicle-stimulating hormone (FSH), thus reducing estrogen synthesis.(1) It also binds to androgen (AR), progesterone (PR), and estrogen (ER) receptors in the human endometrial tissue but not to steroid hormone binding globulin or corticord-binding globulin.(2) Gestrinone binds to AR and PR with EC50 values of approximately 20 and 30 nM, respectively.(3) These values reflect approximately 5-6 fold lower affinity than testosterone and progesterone, the natural AR and PR ligands, for these receptors.(3)
Synonyms Dimetriose, Dimetrose, Nemestran, Gestrigone, Tridomose, Ethylnorgestrienone, Gestrinonum
Reference Data

{0} Product Review(s)

0 Product Review(s) Submit review

Be the first one to submit a review

Product Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.