Morphine-3 Sheep Polyclonal Antibody

CAT#: AP09769PU-L

Morphine-3 sheep polyclonal antibody, Ig Fraction

Specifications

Product Data

• Applications: ELISA
• Recommended Dilution: ELISA: 1.5μg/ml.
• Host: Sheep
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Morphine (3)-BSA
• Specificity: This antibody reacts to Morphine (3).
• Formulation: 20mM Phosphate, 150mM Sodium Chloride, pH 7.2 containing 0.09% Sodium Azide as preservative
  State: Ig Fraction
  State: Liquid Ig fraction prepared by Caprylic Acid and Ammonium Sulphate precipitation procedures
• Concentration: 6.55mg/ml (U.V. abs @ 280nm)
• Background: Morphine is thought to produce reinforcement phenomena via stimulation of mu, delta, and kappa opioid receptors that regulate stress perception, pain control, reward behavior, and neurohormone secretion in reward-relevant brain systems. It has the highest affinity for mu, followed by delta and kappa. Rapid activation of the mu opioid receptor by morphine results in a euphoric phenotype, thus conferring the reinforcing effects of the drug. This activation is accompanied by extracellular dopamine release, which alters several events related to the cAMP signal transduction pathway. Of particular significance is that CREB seems to be modified by morphine, thereby affecting addictive behavioral phenomena, such as withdrawal symptoms.
• Synonyms: 3 Carboxymethyl Morphine