CSEN (KCNIP3) (N-term) Rabbit Polyclonal Antibody
Specifications
Product Data | |
Applications | ELISA, IF, IHC, WB |
Recommended Dilution | ELISA: 1/1,000. Western blot: 1/1,000. Immunofluorescence: 1/10-1/50. Immunohistochemistry on Paraffin Sections: 1/50-1/100. |
Reactivities | Human, Mouse |
Host | Rabbit |
Isotype | Ig |
Clonality | Polyclonal |
Immunogen | This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1~30 amino acids from the N-terminal region of Human KChIP3. |
Specificity | This antibody detects KChIP3 at N-term. |
Formulation | PBS with 0.09% (W/V) Sodium Azide State: Purified State: Liquid purified Ig fraction |
Concentration | lot specific |
Purification | Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Storage | Store undiluted at 2-8°C fore month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Gene Name | potassium voltage-gated channel interacting protein 3 |
Database Link | |
Background | KChIP3 is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein is also shown to function as a calcium-regulated transcriptional repressor, and to interact with presenilins. Mutations in the presenilin genes have been implicated in Alzheimer's disease. Due to utilization of an alternate in-frame translation start codon, the gene for this protein encodes two isoforms with different sizes. |
Synonyms | KCNIP3, CSEN, DREAM, KCHIP3, DRE-antagonist modulator |
Note | Calculated Molecular weight: 29231 Da |
Reference Data |
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