LATS2 (Center) Rabbit Polyclonal Antibody

CAT#: AP13576PU-N

LATS2 (Center) rabbit polyclonal antibody, Purified

Product Images

The anti-LATS2 Pab is used in Western blot to detect LATS2 in NIH/3T3 cell lysate.

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  Formalin-fixed and paraffin-embedded human skeletal muscle tissue reacted with LATS2 antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: ELISA: 1/1,000.
  Western blotting: 1/1,000.
  Immunohistochemistry: 1/10 - 1/50.
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 228-258 amino acids from the center region of human LATS2.
• Specificity: This antibody reacts to LATS2.
• Formulation: PBS with 0.09% (W/V) sodium azide
  State: Purified
  State: Liquid purified Ig
• Concentration: lot specific
• Purification: Saturated Ammonium Sulfate (SAS) Precipitation followed by Dialysis against PBS
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: large tumor suppressor kinase 2
• Database Link:
  Entrez Gene 26524 Human
• Background: LATS2 is a serine/threonine protein kinase belonging to the LATS tumor suppressor family. This protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.
• Synonyms: LATS2, KPM, Serine/threonine-protein kinase LATS2, EC=2.7.11.1, Large tumor suppressor homolog 2, Serine/threonine-protein kinase kpm, Kinase phosphorylated during mitosis protein, Warts-like kinase