COQ3 Rabbit Polyclonal Antibody
Other products for "COQ3"
Specifications
Product Data | |
Applications | WB |
Recommended Dilution | ELISA: 1/1,000. Western blotting: 1/100 - 1/500. |
Reactivities | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | KLH conjugated synthetic peptide selected from the Center region of human COQ3 |
Specificity | This antibody reacts to COQ3. |
Formulation | PBS with 0.09% (W/V) sodium azide State: Liquid purified Ig |
Concentration | lot specific |
Purification | Affinity chromatography on Protein A |
Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Gene Name | Homo sapiens coenzyme Q3, methyltransferase (COQ3) |
Database Link | |
Background | Ubiquinone, also known as coenzyme Q, or Q, is a critical component of the electron transport pathways of both eukaryotes and prokaryotes (Jonassen and Clarke, 2000 [PubMed 10777520]). This lipid consists of a hydrophobic isoprenoid tail and a quinone head group. The tail varies in length depending on the organism, but its purpose is to anchor coenzyme Q to the membrane. The quinone head group is responsible for the activity of coenzyme Q in the respiratory chain. COQ3 is an O-methyltransferase required for 2 steps in the biosynthetic pathway of coenzyme Q. This enzyme methylates an early coenzyme Q intermediate, 3,4-dihydroxy-5-polyprenylbenzoic acid, as well as the final intermediate in the pathway, converting demethyl-ubiquinone to coenzyme Q. The COQ3 is also capable of methylating the distinct prokaryotic early intermediate 2-hydroxy-6-polyprenyl phenol. |
Synonyms | DHHB methyltransferase, DHHB-MTase |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Metabolic pathways, Ubiquinone and other terpenoid-quinone biosynthesis |
Documents
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