GDNF (N-term) Rabbit Polyclonal Antibody

CAT#: AP18033PU-N

GDNF (N-term) rabbit polyclonal antibody

Product Images

Western blot analysis of GDNF Antibody (N-term) in NIH-3T3 cell line lysates (35ug/lane). GDNF (arrow) was detected using the purified Pab.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1,000.
  Western blotting: 1/100 - 1/500.
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide selected from the N-terminal region of human GDNF
• Specificity: This antibody reacts to GDNF.
• Formulation: PBS with 0.09% (W/V) sodium azide
  State: Liquid purifeid Ig
• Concentration: lot specific
• Purification: Affinity chromatography on Protein A
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens glial cell derived neurotrophic factor (GDNF), transcript variant 1
• Database Link:
  Entrez Gene 14573 MouseEntrez Gene 2668 Human
• Background: GDNF is a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. In addition to the transcript encoding GDNF, two additional alternative transcripts encoding distinct proteins, referred to as astrocyte-derived trophic factors, have also been described.
• Synonyms: Glial cell line-derived neurotrophic factor, Astrocyte-derived trophic factor, ATF

Reference Data

• Protein Families: Druggable Genome, Secreted Protein, Transmembrane