Neurotensin Receptor 2 (NTSR2) (Internal) Rabbit Polyclonal Antibody

CAT#: AP20070PU-N

Neurotensin Receptor 2 (NTSR2) (Internal) rabbit polyclonal antibody, Aff - Purified

Product Images

Immunohistochemistry: NTSR2 antibody staining of Formalin-Fixed, Paraffin-Embedded Human Adrenal.

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  Immunohistochemistry: NTSR2 antibody staining of Formalin-Fixed, Paraffin-Embedded Human Brain, Cortex.

Specifications

Product Data

• Applications: ELISA, IHC
• Recommended Dilution: ELISA.
  Immunohistochemistry on Paraffin Sections: 10 - 12 µg/ml.
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic 16 amino acid peptide from internal region of human NTSR2
• Specificity: Reacts with internal region of Neurotensin Receptor Type 2 (NTR2/NTSR2).
• Formulation: PBS containing 0.09% Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: 1 mg/ml
• Purification: Immunoaffinity Chromatography
• Gene Name: Homo sapiens neurotensin receptor 2 (NTSR2)
• Database Link:
  Entrez Gene 18217 MouseEntrez Gene 64636 RatEntrez Gene 23620 Human
• Background: Neurotensin (NT) initiates an intracellular response by interacting with the G protein-coupled receptors NTR1 (NTS1 receptor, high affinity NTR) and NTR2 (NTS2 receptor, levocabastine-sensitive neurotensin receptor), and the type I receptor NTR3 (NTS3 receptor, sortilin-1, Gp95). NT has a wide distribution in regions of the brain and in peripheral tissues where NT receptors can contribute to hypotension, hyperglycemia, hypothermia, antinociception and regulation of intestinal motility and secretion. HL-60 cells express NTR1, which can couple to Gq, Gi/o or Gs. Alternative splicing of rat NTR2 can generate a 5-transmembrane domain variant isoform that is coexpressed with the full length NTR2 throughout the brain and spinal cord. NTR3 activation in the murine microglial cell line N11 induces MIP-2, MCP-1, IL-1β and TNFα in an ERK1/2 and Akt kinase-dependent manner.
  NTR2, a Neurotensin Receptor, is primarily expressed in brain neurons and astrocytes. It is activated by neurotensin and by levocabastine, a histamine H1 antagonist.
• Synonyms: NT-R-2, NTR2, NTSR2

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Neuroactive ligand-receptor interaction