ATRIP Rabbit Polyclonal Antibody

CAT#: AP20204PU-N

ATRIP rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of ATRIP antibody in extracts from NIH/3T3 cells treated with PMA 125ng/ml 30'.

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  Immunohistochemistry Analysis: ATRIP antibody staining of Paraffin-Embedded Human lung colon carcinoma tissue.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: Western blot: 1/500-1/1000.
  Immunofluorescence: 1/50-1/200.
  Immunohistochemistry on Paraffin Sections: 1/50-1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to amino acids 30-76 of Human ATRIP
• Specificity: This antibody antibody detects endogenous levels of ATRIP protein.
• Formulation: Phosphate buffered saline (PBS), pH~7.2 containing 0.05% Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE)
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography using epitope-specific immunogen
• Predicted Protein Size: ~ 80 kDa
• Gene Name: Homo sapiens ATR interacting protein (ATRIP), transcript variant 2
• Database Link:
  Entrez Gene 235610 MouseEntrez Gene 301014 RatEntrez Gene 84126 Human
• Background: The product of the ATRIP gene is an essential component of the DNA damage checkpoint, and binds to single stranded DNA coated with replication protein A that accumulates at sites of DNA damage. The encoded protein interacts with the ataxia telangiectasia and Rad3 related protein, a checkpoint kinase, resulting in accumulation of the kinase at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene.
• Synonyms: ATR-interacting protein