HNRNPD Rabbit Polyclonal Antibody

CAT#: AP20246PU-N

HNRNPD rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of hnRPD antibody Cat.-No AP20246PU-N in extracts from 293 cells.

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  Immunohistochemistry analyzes of hnRPD antibody Cat.-No AP20246PU-N in paraffin-embedded human lung carcinoma tissue.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: Western blot: 1/500-1/1000.
  Immunoflourescence: 1/50-1/200.
  Immunohistochemistry on Paraffin Sections: 1/50-1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of hnRPD protein.
• Formulation: Phosphate Buffered Saline (PBS), pH~7.2
  State: Aff - Purified
  State: Liquid purifed Ig fraction (> 95% by SDS-PAGE)
  Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purification: Affinity-chromatography using epitope-specific immunogen
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~38 kDa
• Gene Name: Homo sapiens heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) (HNRNPD), transcript variant 4
• Database Link:
  Entrez Gene 11991 MouseEntrez Gene 79256 RatEntrez Gene 3184 Human
  UniProt ID Q14103
• Background: hnRNP D/AUF1 binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3' untranslated regions of many protooncogenes and cytokine mRNAs. It also binds to double and single stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single stranded nonmonotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. It may be involved in translationally coupled mRNA turnover (referenced from swissprot).
• Synonyms: AUF1, HNRPD, Heterogeneous nuclear ribonucleoprotein D0

Reference Data

• Protein Families: Druggable Genome, Transcription Factors